Drugs in development · updated 30 October 2026
Sepsis: drugs in development
As of 30 October 2026 there are 39 active clinical trials (recruiting or ongoing, phases I–III) on 48 drugs for sepsis. 14 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Interferon gamma | III | 1 | NCT05843786 |
| Pralurbactam | III | 1 | NCT07089186 |
| AZD4144 | II | 1 | NCT07215702 |
| AZD7760 | I–II | 1 | NCT06749457 |
| Pentaglobin | II | 1 | NCT03334006 |
| Plasminogen | II | 1 | NCT06381661 |
| Racecadotril | I–II | 1 | NCT07454421 |
| Silymarin | II | 1 | NCT07572552 |
| Sivelestat | II | 1 | NCT06381661 |
| Tazocin | I–II | 1 | NCT07096310 |
| YD0743 | II | 1 | NCT07413094 |
| BAY3389934 | I | 1 | NCT06854640 |
| DNase I | I | 1 | NCT05453695 |
| OPT101 | I | 1 | NCT06669403 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Fludrocortisone acetateFlorinef® | III | 3 | NCT07898462 |
| HydrocortisoneHydrocortison cream, Khindivi® | III | 3 | NCT07332325 |
| MeropenemMeropenem And Sodium Chloride In Duplex Container®, Merrem Iv® | III | 3 | NCT07813767 |
| ClarithromycinBiaxin Xl®, Biaxin® | III | 2 | NCT07834346 |
| Interferon gamma-1bActimmune® | II–III | 2 | NCT06694740 |
| Avibactam | III | 1 | NCT07063095 |
| CeftazidimeCeftazidime In Dextrose Container®, Ceptaz® | III | 1 | NCT07063095 |
| ColistinColy-Mycin S® | III | 1 | NCT07089186 |
| DexamethasoneDexametasone, Dextenza | III | 1 | NCT07576660 |
| DexmedetomidineIgalmi®, Precedex® | III | 1 | NCT07569536 |
| FosfomycinContepo®, Monurol® | III | 1 | NCT07063095 |
| Norepinephrine | III | 1 | NCT05179499 |
| Penicillin GBenzylpenicillin, Penicillin G Potassium In Plastic Container® | III | 1 | NCT07575009 |
| PivmecillinamPivya | III | 1 | NCT07407673 |
| PrednisolonePrednisolon, Prenisolone | III | 1 | NCT06472219 |
Sorted by most advanced phase and number of active trials. Showing 15 of 34 drugs.
All 48 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Septic shock 26 drugs
- Neonatal sepsis 3 drugs
- Bacteremia 8 drugs
- Pneumonia 63 drugs
- Shock 9 drugs
- Acute kidney injury 37 drugs
- Meningitis 5 drugs
- Urinary tract infection 15 drugs
- Cholera 3 drugs
- Critical illness 19 drugs
- Candidemia 3 drugs
- Invasive candidiasis 3 drugs
Broader categories
- Inflammation 85 drugs
- Infection 71 drugs
- Respiratory disease 57 drugs
- Shock 9 drugs
- Lung disease 104 drugs
- Urogenital Diseases 16 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D018805 “Sepsis”.