Drugs in development · updated 30 October 2026
Shock: drugs in development
As of 30 October 2026 there are 6 active clinical trials (recruiting or ongoing, phases I–III) on 9 drugs for shock. 2 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Centhaquine | III | 1 | NCT05251181 |
| NoradrenalineNoradrenalin | III | 1 | NCT05931601 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| DopamineDopamine Hydrochloride In Dextrose 5%®, Dopamine Hydrochloride In Dextrose 5% In Plastic Container® | III | 1 | NCT04750070 |
| EpinephrineAdrenaline, Adrenalin® | III | 1 | NCT04750070 |
| FentanylFentanyl Citrate Buccal Tablet, Subsys® | III | 1 | NCT05437575 |
| KetamineKetalar® | III | 1 | NCT05437575 |
| MidazolamMidazolam Hydrochloride (Autoinjector)®, Midazolam In 0.8% Sodium Chloride® | III | 1 | NCT07155265 |
| RemimazolamByfavo® | III | 1 | NCT07155265 |
| Sodium BicarbonateSodium Bicarbonate In Plastic Container® | III | 1 | NCT05697770 |
Sorted by most advanced phase and number of active trials.
All 9 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Septic shock 26 drugs
- Cytokine release syndrome 21 drugs
- Cardiogenic shock 13 drugs
- Sepsis 48 drugs
- Heart failure 104 drugs
- Multiple myeloma 272 drugs
- Inflammation 85 drugs
- Hemorrhagic shock 3 drugs
- Acute kidney injury 37 drugs
- Immune System Diseases 54 drugs
- Immunoproliferative disorder 16 drugs
- Non-Hodgkin lymphoma 269 drugs
Broader categories
- Nutritional and metabolic diseases 5 drugs
- Infection 71 drugs
- Sepsis 48 drugs
- Inflammation 85 drugs
- Metabolic disease 30 drugs
- Nutrition disorder 10 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D012769 “Shock”.