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Drugs in development · updated 30 October 2026

Ivosidenib: clinical trials and development status

Other names and codes: AG-120, Tibsovo, Tidhesco

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 4 May 2023

As of 30 October 2026 Ivosidenib is in 40 active clinical trials (recruiting or ongoing, phases I–III) for 26 diseases. The most advanced phase is III.

40Active trials
IIIMost advanced phase
26Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Ivosidenib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Acute myeloid leukemiaIII19NCT03839771
Myelodysplastic SyndromesIII5NCT06465953
Biliary tract neoplasmIII3NCT07745296
CholangiocarcinomaIII3NCT07745296
LeukemiaIII2NCT03173248
MetastasisIII2NCT06127407
Myeloproliferative disordersII3NCT04493164
EpendymomaII2NCT03155620
Ewing sarcomaII2NCT03155620
GliomaII2NCT03155620
HepatoblastomaII2NCT03155620
Langerhans-cell histiocytosisII2NCT03155620
MedulloblastomaII2NCT03155620
NeuroblastomaII2NCT03155620
Non-Hodgkin lymphomaII2NCT03155620
OsteosarcomaII2NCT03155620
Peripheral primitive neuroectodermal tumorII2NCT03155620
Rhabdoid tumorII2NCT03155620
RhabdomyosarcomaII2NCT03155620
SarcomaII2NCT03155620
Wilms TumorII2NCT03155620
Central nervous system neoplasmII1NCT03155620
ChondrosarcomaII1NCT04278781
Histiocytic sarcomaII1NCT03155620
Juvenile xanthogranulomaII1NCT03155620
Hematologic neoplasmI1NCT02074839

Everything on Ivosidenib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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