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Drugs in development · updated 30 October 2026

Pembrolizumab: clinical trials and development status

Other names and codes: KEYTRUDA, MK-3475

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 17 July 2015

As of 30 October 2026 Pembrolizumab is in 1,102 active clinical trials (recruiting or ongoing, phases I–III) for 205 diseases. The most advanced phase is III.

1,102Active trials
IIIMost advanced phase
205Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Pembrolizumab and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 205 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Non-small-cell lung carcinomaIII191NCT06623422
Head and neck squamous cell carcinomaIII112NCT06589804
MelanomaIII106NCT02506153
Triple-negative breast neoplasmIII90NCT02954874
Breast neoplasmIII83NCT02954874
MetastasisIII83NCT07715396
Lung neoplasmIII76NCT04267848
Colorectal neoplasmIII64NCT07750158
NeoplasmIII61NCT07566156
Renal cell carcinomaIII58NCT04736706
Head and neck neoplasmsIII50NCT06525220
Endometrial neoplasmIII46NCT07578649
Ovarian neoplasmIII46NCT07286266
Bladder neoplasmIII43NCT07566156
Stomach neoplasmIII40NCT06093425
Transitional cell carcinomaIII40NCT07566156
Uterine cervix neoplasmIII35NCT07216703
CarcinomaIII21NCT06589804
GlioblastomaIII19NCT06556563
Squamous cell carcinomaIII19NCT04747054
Biliary tract neoplasmIII16NCT06282575
Brain NeoplasmsIII16NCT05317858
Lung small cell carcinomaIII16NCT04624204
CholangiocarcinomaIII15NCT06282575
Esophageal squamous cell carcinomaIII15NCT04807673
Merkel cell carcinomaII–III14NCT06947928
AdenocarcinomaIII13NCT07673887
Fallopian tube neoplasmIII12NCT05116189
Mouth NeoplasmsIII12NCT06589804
Oropharyngeal NeoplasmsIII11NCT05721755

Everything on Pembrolizumab

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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