Phuturdex › Diseases › Osteoarthritis
Drugs in development · updated 30 October 2026
Osteoarthritis: drugs in development
As of 30 October 2026 there are 21 active clinical trials (recruiting or ongoing, phases I–III) on 20 drugs for osteoarthritis. 7 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| EloralintideLY3841136 | III | 1 | NCT07353931 |
| PTP-01 | III | 1 | NCT07219771 |
| Allocetra | II | 2 | NCT07580716 |
| KBP-336 | II | 1 | NCT06833749 |
| TPX-100 | II | 1 | NCT06865079 |
| GNSC-001 | I | 1 | NCT05835895 |
| Microneedle | I | 1 | NCT07085520 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Pentosan Polysulfate SodiumElmiron® | II–III | 2 | NCT04809376 |
| IbuprofenAdvil®, Caldolor® | III | 1 | NCT05318521 |
| OnabotulinumtoxinABotox, Botox Cosmetic® | II–III | 1 | NCT06902805 |
| OrforglipronFoundayo® | III | 1 | NCT07153471 |
| Solumedrol | II–III | 1 | NCT07703280 |
| Tranexamic AcidTransexamic acid, Lysteda® | III | 1 | NCT07825350 |
| CannabidiolEpidiolex, Epidyolex® | I–II | 1 | NCT06414473 |
| Triamcinolone Acetonidezilretta, Kenalog { | II | 1 | NCT06237153 |
| DenosumabProlia, Degevma® | I | 1 | NCT07085520 |
| DiclofenacVoltaren Topical Gel, Zueino® | I | 1 | NCT05254574 |
| AnakinraKINERET | Early I | 1 | NCT03968913 |
| MetforminRiomet Er®, Glumetza® | Early I | 1 | NCT07065591 |
| MontelukastSingulair® | Early I | 1 | NCT04572256 |
Sorted by most advanced phase and number of active trials.
All 20 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Knee osteoarthritis 37 drugs
- Hip osteoarthritis 4 drugs
- Obesity 233 drugs
- Chronic pain 40 drugs
- Anterior cruciate ligament injury 5 drugs
- Knee Injuries 3 drugs
- Postoperative pain 50 drugs
- Pain 75 drugs
- Depression 73 drugs
- Musculoskeletal disorder 22 drugs
- Overweight 139 drugs
- Inflammation 85 drugs
Broader categories
- Rheumatic Diseases 30 drugs
- Joint Diseases 6 drugs
- Musculoskeletal disorder 22 drugs
- Arthritis 13 drugs
- Nutritional and metabolic diseases 5 drugs
- Human body weight 13 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D010003 “Osteoarthritis”.