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Drugs in development · updated 30 October 2026

Larotrectinib: clinical trials and development status

Other names and codes: BAY2757556, Vitrakvi

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 19 September 2019

As of 30 October 2026 Larotrectinib is in 14 active clinical trials (recruiting or ongoing, phases I–III) for 42 diseases. The most advanced phase is II.

14Active trials
IIMost advanced phase
42Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Larotrectinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 42 diseases.

DiseaseMost advanced phaseActive trialsReference trial
GliomaII4NCT02465060
Central nervous system neoplasmII3NCT03155620
Colorectal neoplasmII2NCT02465060
EpendymomaII2NCT03155620
HepatoblastomaII2NCT03155620
Langerhans-cell histiocytosisII2NCT03155620
Lung neoplasmII2NCT02465060
LymphomaII2NCT02465060
MedulloblastomaII2NCT03155620
Multiple myelomaII2NCT02465060
NeoplasmII2NCT05783323
NeuroblastomaII2NCT03155620
Non-Hodgkin lymphomaII2NCT03155620
OsteosarcomaII2NCT03155620
Peripheral primitive neuroectodermal tumorII2NCT03155620
Rhabdoid tumorII2NCT03155620
RhabdomyosarcomaII2NCT03155620
SarcomaII2NCT03155620
Thyroid neoplasmII2NCT02465060
Wilms TumorII2NCT03155620
Bladder neoplasmII1NCT02465060
Breast neoplasmII1NCT02465060
Colonic neoplasmII1NCT02465060
Endometrial neoplasmII1NCT02465060
Esophageal neoplasmII1NCT02465060
Ewing sarcomaII1NCT03155620
Hematologic neoplasmII1NCT02465060
Hepatocellular carcinomaII1NCT02465060
Histiocytic sarcomaII1NCT03155620
Juvenile xanthogranulomaII1NCT03155620

Everything on Larotrectinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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