Phuturdex › Diseases › Hepatocellular carcinoma
Drugs in development · updated 30 October 2026
Hepatocellular carcinoma: drugs in development
As of 30 October 2026 there are 356 active clinical trials (recruiting or ongoing, phases I–III) on 266 drugs for hepatocellular carcinoma. 166 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
Sorted by most advanced phase and number of active trials. Showing 40 of 166 drugs.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| Bevacizumabavastin, MVASI | II–III | 68 | NCT06109272 |
| LenvatinibLenvatinib Mesilate Capsules, Levatinib | III | 51 | NCT05301842 |
| AtezolizumabTecentriq, MPDL3280A | II–III | 44 | NCT06109272 |
| DurvalumabMEDI4736, Imfinzi® | II–III | 42 | NCT06109272 |
| TremelimumabImjudo®, Tremelimumab AstraZeneca® | II–III | 31 | NCT06109272 |
| NivolumabOpdivo, ONO-4538 | III | 24 | NCT07620574 |
| TislelizumabTisleizumab, Tiselizumab | III | 20 | NCT07475026 |
| IpilimumabYERVOY, ipililumab IV | III | 12 | NCT07166406 |
| RegorafenibRegorafinib, BAY73-4506 | II–III | 12 | NCT07392866 |
| CabozantinibResniben®, Cabometyx® | III | 11 | NCT07620574 |
| SorafenibNexavar®, Sorafenib Accord® | III | 9 | NCT03298451 |
| TACE | II–III | 9 | NCT06644937 |
| OxaliplatinOxaliplatine, Oxaliplain | II–III | 7 | NCT07490262 |
| ToripalimabJS001, Teripalimab | II–III | 6 | NCT03859128 |
| Fluorouracil5-Fluorouracil, Adrucil | III | 5 | NCT03017326 |
Sorted by most advanced phase and number of active trials. Showing 15 of 100 drugs.
All 266 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Broader categories
- Digestive System Diseases 36 drugs
- Adenocarcinoma 111 drugs
- Glandular and epithelial neoplasm 12 drugs
- Carcinoma 137 drugs
- Digestive system neoplasm 37 drugs
- Liver disease 33 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D006528 “Carcinoma, Hepatocellular”. Prevalence: Orphanet.