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Drugs in development · updated 30 October 2026

Ivonescimab: clinical trials and development status

Other names and codes: AK112

FDA substance registryNot approved in the USNo EMA authorisationEstimated launch Dec 2027 – Oct 2028 (Phuturdex estimate)

As of 30 October 2026 Ivonescimab is in 151 active clinical trials (recruiting or ongoing, phases I–III) for 48 diseases. The most advanced phase is III.

151Active trials
IIIMost advanced phase
48Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Ivonescimab and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 48 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Non-small-cell lung carcinomaIII26NCT05899608
Triple-negative breast neoplasmIII8NCT06767527
Lung small cell carcinomaIII6NCT07010263
Pancreatic neoplasmIII6NCT06953999
Biliary tract neoplasmIII5NCT06591520
Head and neck squamous cell carcinomaIII5NCT07264075
CholangiocarcinomaII–III2NCT07765433
Transitional cell carcinomaII–III2NCT07815665
Head and neck neoplasmsIII1NCT07264075
Colorectal neoplasmII8NCT07809893
Breast neoplasmII6NCT07743632
Lung neoplasmII4NCT07472478
NeoplasmII4NCT01042379
Renal cell carcinomaII4NCT07226544
Esophageal neoplasmII3NCT07070466
Hepatocellular carcinomaII3NCT07052253
Malignant mesotheliomaII3NCT06840834
Nasopharyngeal CarcinomaII3NCT07064902
Stomach neoplasmII3NCT07070466
Esophageal squamous cell carcinomaII2NCT07188103
MetastasisII2NCT06846346
Rectal neoplasmII2NCT07162714
Salivary gland neoplasmII2NCT06805617
Uterine cervix neoplasmII2NCT06925724
AdenocarcinomaII1NCT06846346
Adenoid cystic carcinomaII1NCT06805617
Adrenocortical carcinomaII1NCT07743138
Bladder neoplasmI–II1NCT06957561
Brain NeoplasmsII1NCT06793332
Colonic neoplasmII1NCT06790212

Everything on Ivonescimab

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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