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Drugs in development · updated 30 October 2026

Zanzalintinib: clinical trials and development status

Other names and codes: XL092

FDA substance registryNot approved in the USNo EMA authorisationEstimated launch Dec 2027 – Oct 2028 (Phuturdex estimate)

As of 30 October 2026 Zanzalintinib is in 48 active clinical trials (recruiting or ongoing, phases I–III) for 37 diseases. The most advanced phase is III.

48Active trials
IIIMost advanced phase
37Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Zanzalintinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 37 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Renal cell carcinomaIII9NCT07489495
Hepatocellular carcinomaIII7NCT07620574
MetastasisII–III6NCT06943755
Colorectal neoplasmIII5NCT07620574
Head and neck squamous cell carcinomaII–III3NCT06082167
NeoplasmIII3NCT07620574
Neuroendocrine tumorII–III3NCT06943755
CarcinomaIII1NCT07227402
Microsatellite instabilityIII1NCT07750158
Prostatic NeoplasmsIII1NCT07620574
Anaplastic thyroid carcinomaII2NCT07470489
Bone neoplasmII2NCT06571734
Brain NeoplasmsII2NCT07428616
Clear-cell metastatic renal cell carcinomaII2NCT07043608
Head and neck neoplasmsII2NCT07484139
SarcomaII2NCT07283731
Thyroid neoplasmII2NCT06959511
Adenocarcinoma, FollicularII1NCT06959641
EsthesioneuroblastomaII1NCT07527169
Ewing sarcomaII1NCT06571734
FibrosisI–II1NCT07042919
Germ cell and embryonal neoplasmsI–II1NCT06937866
LeiomyosarcomaII1NCT06571734
Liver neoplasmII1NCT07226063
MeningiomaII1NCT07428616
OsteosarcomaII1NCT06571734
Papillary thyroid cancerII1NCT06959641
ParagangliomaII1NCT07714551
PheochromocytomaII1NCT07714551
Synovial sarcomaII1NCT06571734

Everything on Zanzalintinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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