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Drugs in development · updated 30 October 2026

Trastuzumab deruxtecan: clinical trials and development status

Other names and codes: DS-8201a, Enhertu

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 18 January 2021

As of 30 October 2026 Trastuzumab deruxtecan is in 109 active clinical trials (recruiting or ongoing, phases I–III) for 48 diseases. The most advanced phase is III.

109Active trials
IIIMost advanced phase
48Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Trastuzumab deruxtecan and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 48 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Breast neoplasmIII47NCT07060807
MetastasisIII17NCT04784715
Stomach neoplasmIII10NCT06731478
Non-small-cell lung carcinomaIII7NCT06899126
Brain NeoplasmsIII5NCT04739761
Endometrial neoplasmIII4NCT07022483
Ovarian neoplasmIII4NCT06819007
AdenocarcinomaIII3NCT04704934
Biliary tract neoplasmIII1NCT06467357
Breast diseaseIII1NCT04784715
Ovarian epithelial carcinomaIII1NCT06819007
Uterine neoplasmIII1NCT06989112
Colorectal neoplasmII9NCT07691489
Pancreatic neoplasmII5NCT07825753
Triple-negative breast neoplasmII5NCT07151586
Colonic neoplasmII4NCT07691489
Esophageal neoplasmII3NCT04379596
NeoplasmII3NCT02693535
Rectal neoplasmII3NCT07691489
Salivary gland neoplasmII3NCT05408845
Esophagus adenocarcinomaII2NCT05480384
Fallopian tube neoplasmI–II2NCT05417594
Prostatic NeoplasmsII2NCT06610825
Residual neoplasmII2NCT05965479
AstrocytomaI–II1NCT05417594
CarcinomaII1NCT04379596
Desmoplastic small-round-cell tumorII1NCT04616560
GlioblastomaII1NCT06058988
GliomaI–II1NCT05417594
Hepatocellular carcinomaI–II1NCT05824975

Everything on Trastuzumab deruxtecan

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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