Phuturdex › Diseases › Squamous cell neoplasm
Drugs in development · updated 30 October 2026
Squamous cell neoplasm: drugs in development
As of 30 October 2026 there are 8 active clinical trials (recruiting or ongoing, phases I–III) on 16 drugs for squamous cell neoplasm. 6 are experimental, that is not yet approved in the United States.
Summary updated every week · data as of 30 October 2026. In Phuturdex you get the full detail of every drug and an email when an alert is published on the ones you follow.
Sign in free →Experimental drugs
Not yet approved by the US FDA for any indication.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| AnlotinibAL3818, Anrotinib | II | 1 | NCT05252078 |
| BenmelstobartTQB2450 | II | 1 | NCT05252078 |
| INBRX-106 | I–II | 1 | NCT04198766 |
| Nivo800 | I | 1 | NCT07460765 |
| R-5780 | I | 1 | NCT06398418 |
| ZW251 | I | 1 | NCT07164313 |
Sorted by most advanced phase and number of active trials.
Approved drugs in new trials
Approved by the US FDA for at least one indication, not necessarily this disease, and now in active trials on it.
| Drug | Most advanced phase | Active trials | Reference trial |
|---|---|---|---|
| PaclitaxelTaxol, Paxlitaxel | I–II | 2 | NCT04198766 |
| Bevacizumabavastin, MVASI | II | 1 | NCT05797246 |
| CisplatinCis Platinum, Cisplatine | I–II | 1 | NCT04198766 |
| CyclophosphamideCyclophosphamid, Cytoxan | II | 1 | NCT03935893 |
| FludarabineFludara, FLUDARABIN | II | 1 | NCT03935893 |
| GemcitabineGemcitabin, Gemzar | I–II | 1 | NCT04198766 |
| PembrolizumabKEYTRUDA, MK-3475 | I–II | 1 | NCT04198766 |
| PemetrexedAxtle®, Pemfexy® | I–II | 1 | NCT04198766 |
| CarboplatinCarboplatine, Paraplatin | I | 1 | NCT04391049 |
| NivolumabOpdivo, ONO-4538 | I | 1 | NCT07460765 |
Sorted by most advanced phase and number of active trials.
All 16 drugs, with the details
In Phuturdex every drug has all its trials, sponsors and countries, FDA and EMA approvals, orphan designations and safety alerts. Free until 31 March 2027.
Open in Phuturdex →Specific forms
- Esophageal squamous cell carcinoma 115 drugs
- Squamous cell carcinoma 72 drugs
- Head and neck squamous cell carcinoma 321 drugs
- Non-small-cell lung carcinoma 726 drugs
- Head and neck neoplasms 184 drugs
- Esophageal neoplasm 191 drugs
- Metastasis 493 drugs
- Uterine cervix neoplasm 224 drugs
- Melanoma 352 drugs
- Esophagus adenocarcinoma 82 drugs
- Colorectal neoplasm 534 drugs
- Triple-negative breast neoplasm 334 drugs
Broader categories
- Neoplasm 671 drugs
- Glandular and epithelial neoplasm 12 drugs
- Carcinoma 137 drugs
- Digestive System Diseases 36 drugs
- Adenocarcinoma 111 drugs
- Digestive system neoplasm 37 drugs
Source: Phuturdex analysis of ClinicalTrials.gov data (U.S. National Library of Medicine), updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III, with at least one identified drug; phase and sites refer to the trials on this disease. Disease name: Wikidata; NLM MeSH term: D018307 “Neoplasms, Squamous Cell”.