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Drugs in development · updated 30 October 2026

PF-08634404: clinical trials and development status

Development codeNot approved in the USNo EMA authorisationEstimated launch Apr 2030 – Feb 2031 (Phuturdex estimate)

As of 30 October 2026 PF-08634404 is in 11 active clinical trials (recruiting or ongoing, phases I–III) for 26 diseases. The most advanced phase is III.

11Active trials
IIIMost advanced phase
26Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow PF-08634404 and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
CarcinomaIII3NCT07222566
Lung neoplasmIII3NCT07222566
MetastasisIII3NCT07222800
Non-small-cell lung carcinomaIII3NCT07222566
Lung small cell carcinomaII–III2NCT07226999
Colonic diseaseIII1NCT07222800
Colonic neoplasmIII1NCT07222800
Colorectal neoplasmIII1NCT07222800
Digestive System DiseasesIII1NCT07222800
Digestive system neoplasmIII1NCT07222800
Endometrial neoplasmIII1NCT07578649
Esophagus adenocarcinomaII–III1NCT07392892
Gastrointestinal diseaseIII1NCT07222800
Gastrointestinal neoplasmIII1NCT07222800
Intestinal diseaseIII1NCT07222800
Intestinal neoplasmIII1NCT07222800
Rectal diseaseIII1NCT07222800
Stomach neoplasmII–III1NCT07392892
Bladder neoplasmI–II1NCT07421700
Clear-cell metastatic renal cell carcinomaI–II1NCT07227415
Hepatocellular carcinomaI–II1NCT07227012
Kidney neoplasmI–II1NCT07227415
Liver neoplasmI–II1NCT07227012
Lung diseaseII1NCT07489066
Renal cell carcinomaI–II1NCT07227415
Transitional cell carcinomaI–II1NCT07421700

Everything on PF-08634404

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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