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Drugs in development · updated 30 October 2026

Selumetinib: clinical trials and development status

Other names and codes: AZD6244, Koselugo

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 17 June 2021

As of 30 October 2026 Selumetinib is in 35 active clinical trials (recruiting or ongoing, phases I–III) for 37 diseases. The most advanced phase is III.

35Active trials
IIIMost advanced phase
37Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Selumetinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 37 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Neurofibromatosis 1III14NCT03871257
Plexiform neurofibromaIII7NCT04924608
Non-small-cell lung carcinomaIII3NCT01933932
MetastasisIII2NCT01933932
EpendymomaII3NCT07707947
Breast neoplasmII2NCT02299999
Endometrial neoplasmII2NCT05564377
Fallopian tube neoplasmII2NCT05564377
MeningiomaII2NCT07707947
NeoplasmI–II2NCT02813135
Neurofibromatosis 2II2NCT07707947
Neuroma, AcousticII2NCT07707947
Ovarian neoplasmII2NCT05564377
AstrocytomaI–II1NCT01089101
Central nervous system neoplasmII1NCT03155620
Ewing sarcomaII1NCT03155620
Gallbladder neoplasmII1NCT02151084
GliomaII1NCT03155620
HepatoblastomaII1NCT03155620
Histiocytic sarcomaII1NCT03155620
Juvenile xanthogranulomaII1NCT03155620
Langerhans-cell histiocytosisII1NCT03155620
MedulloblastomaII1NCT03155620
NeuroblastomaII1NCT03155620
NeurofibrosarcomaI–II1NCT06735820
Non-Hodgkin lymphomaII1NCT03155620
OsteosarcomaII1NCT03155620
PainI–II1NCT01362803
Pancreatic neoplasmI–II1NCT07619521
Peripheral primitive neuroectodermal tumorII1NCT03155620

Everything on Selumetinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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