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Drugs in development · updated 30 October 2026

Trametinib: clinical trials and development status

Other names and codes: Mekinist, Spexotras

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 30 June 2014

As of 30 October 2026 Trametinib is in 71 active clinical trials (recruiting or ongoing, phases I–III) for 58 diseases. The most advanced phase is III.

71Active trials
IIIMost advanced phase
58Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Trametinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 58 diseases.

DiseaseMost advanced phaseActive trialsReference trial
MelanomaIII12NCT06346067
NeoplasmII–III8NCT07440290
Non-small-cell lung carcinomaII–III7NCT07440290
Anaplastic thyroid carcinomaII–III6NCT07440290
Colorectal neoplasmII–III6NCT07440290
GliomaII–III6NCT07440290
Multiple myelomaII–III5NCT07440290
Hematologic neoplasmII–III4NCT07440290
Langerhans-cell histiocytosisII–III4NCT07440290
Papillary thyroid cancerII–III3NCT07440290
AmeloblastomaII–III2NCT06819605
Lymphoproliferative disordersII–III2NCT07440290
Noonan syndromeIII2NCT07817186
Ovarian neoplasmII–III2NCT07440290
Erdheim-Chester diseaseII–III1NCT07440290
Gastrointestinal neoplasmII–III1NCT07440290
Heart failureIII1NCT07817186
Laryngeal neoplasmII–III1NCT07440290
Pancreatic DiseasesII–III1NCT07440290
Thyroid neoplasmII7NCT02465060
Brain NeoplasmsII4NCT02910700
Lung neoplasmII3NCT02465060
MetastasisII3NCT04116541
Neurofibromatosis 1II3NCT03190915
Prostatic NeoplasmsII3NCT02465060
Adenocarcinoma, FollicularII2NCT04544111
Juvenile myelomonocytic leukemiaII2NCT03190915
Pancreatic neoplasmII2NCT02465060
Vascular malformationII2NCT07549646
AstrocytomaII1NCT05180825

Everything on Trametinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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