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Drugs in development · updated 30 October 2026

Datopotamab deruxtecan: clinical trials and development status

Other names and codes: Dato-DXd, DS-1062a, Datroway

FDA verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 4 April 2025

As of 30 October 2026 Datopotamab deruxtecan is in 44 active clinical trials (recruiting or ongoing, phases I–III) for 24 diseases. The most advanced phase is III.

44Active trials
IIIMost advanced phase
24Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Datopotamab deruxtecan and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Non-small-cell lung carcinomaIII21NCT06357533
Breast neoplasmIII18NCT06112379
MetastasisIII6NCT07205822
Bladder neoplasmIII3NCT07720284
CarcinomaIII2NCT06417814
Transitional cell carcinomaIII2NCT07720284
AdenocarcinomaIII1NCT06564844
Triple-negative breast neoplasmII8NCT06176261
Lung neoplasmII3NCT05061550
Ovarian neoplasmII3NCT05489211
Pancreatic neoplasmII3NCT07825753
Colorectal neoplasmII2NCT05489211
Endometrial neoplasmII2NCT05489211
Prostatic NeoplasmsI–II2NCT05417594
Stomach neoplasmII2NCT05489211
AstrocytomaI–II1NCT05417594
Biliary tract neoplasmII1NCT05489211
Brain NeoplasmsII1NCT06822543
Fallopian tube neoplasmI–II1NCT05417594
GliomaI–II1NCT05417594
HemangiosarcomaII1NCT01042379
NeoplasmII1NCT01042379
Residual neoplasmII1NCT07069595
Uterine cervix neoplasmI–II1NCT04644068

Everything on Datopotamab deruxtecan

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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