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Drugs in development · updated 30 October 2026

Defactinib: clinical trials and development status

NLM verified identityApproved in the US (FDA)

As of 30 October 2026 Defactinib is in 26 active clinical trials (recruiting or ongoing, phases I–III) for 36 diseases. The most advanced phase is III.

26Active trials
IIIMost advanced phase
36Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Defactinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov. Showing 30 of 36 diseases.

DiseaseMost advanced phaseActive trialsReference trial
Pancreatic neoplasmII7NCT02465060
GlioblastomaI–II3NCT06630260
Lung neoplasmII3NCT02465060
MetastasisII3NCT07743554
Ovarian neoplasmII3NCT02465060
Colorectal neoplasmII2NCT02465060
Endometrial neoplasmII2NCT02465060
Hematologic neoplasmII2NCT02465060
LymphomaII2NCT02465060
MelanomaII2NCT02465060
Multiple myelomaII2NCT02465060
Non-small-cell lung carcinomaI–II2NCT07020221
Stomach neoplasmII2NCT02465060
Thyroid neoplasmII2NCT02465060
Uterine cervix neoplasmII2NCT02465060
Adenocarcinoma of the lungII1NCT06495125
Appendiceal neoplasmI–II1NCT07020221
Biliary tract neoplasmI–II1NCT07020221
Bladder neoplasmII1NCT02465060
Brain NeoplasmsI–II1NCT06194929
Breast neoplasmII1NCT02465060
CholangiocarcinomaI–II1NCT07020221
Colonic neoplasmII1NCT02465060
Esophageal neoplasmII1NCT02465060
Gastrointestinal neoplasmI–II1NCT07020221
GliomaII1NCT02465060
Hepatocellular carcinomaII1NCT02465060
Neurofibromatosis 1II1NCT07743554
NeurofibrosarcomaII1NCT07743554
Prostatic NeoplasmsII1NCT02465060

Everything on Defactinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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