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Drugs in development · updated 30 October 2026

Tucatinib: clinical trials and development status

Other names and codes: Tukysa

NLM verified identityApproved in the US (FDA)Authorised in the EU (EMA) since 11 February 2021

As of 30 October 2026 Tucatinib is in 35 active clinical trials (recruiting or ongoing, phases I–III) for 26 diseases. The most advanced phase is III.

35Active trials
IIIMost advanced phase
26Diseases studied

Summary updated every week · data as of 30 October 2026. In Phuturdex you can follow Tucatinib and get an email at every change or safety alert.

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Diseases studied

For each disease: the drug’s most advanced phase and active trials, with the reference trial on ClinicalTrials.gov.

DiseaseMost advanced phaseActive trialsReference trial
Breast neoplasmIII18NCT05132582
Colorectal neoplasmIII6NCT05253651
Brain NeoplasmsII3NCT05673928
MetastasisII3NCT05673928
NeoplasmII3NCT02693535
Triple-negative breast neoplasmII3NCT06157892
AdenocarcinomaII2NCT05672524
Meningeal neoplasmII2NCT06016387
Multiple myelomaII2NCT02693535
Non-Hodgkin lymphomaII2NCT02693535
Non-small-cell lung carcinomaII2NCT04579380
Rectal neoplasmII2NCT05672524
Stomach neoplasmII2NCT06157892
Biliary tract neoplasmII1NCT04579380
CholangiocarcinomaII1NCT04430738
Colonic neoplasmI–II1NCT05868226
Esophageal neoplasmII1NCT04430738
Esophagus adenocarcinomaII1NCT04430738
Gallbladder neoplasmII1NCT04430738
HemangiosarcomaII1NCT01042379
Meningeal carcinomatosisII1NCT05800275
Residual neoplasmI–II1NCT05868226
Urologic NeoplasmsII1NCT04579380
Uterine cervix neoplasmII1NCT04579380
Uterine neoplasmII1NCT04579380
Lung neoplasmI1NCT06067776

Everything on Tucatinib

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Source: Phuturdex analysis of ClinicalTrials.gov (U.S. National Library of Medicine), FDA and EMA data, updated 30 October 2026. Active trials = recruiting or ongoing, phases I–III. Diseases are those named by each trial (NLM MeSH terms). The estimated launch, when shown, is a Phuturdex calculation described on the Method page, not official data.

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